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Reductive amination nabh3cn

Na2SO4 and concentrated to dryness.
MeOH dCM ) to provide the pdt as a yellow solid.
After cooling to RT, NaBH3CN (98 mg,.58 mmol) was added to the mixture.
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The org phase was concentrated and the residue was purified by silica gel column chromatography (6:1.1.1 g, 81 Patent Reference: WO, page 108, (10.3 MB).The reaction was stirred at RT for.The mixture was poured into H2O (10 mL) and extracted with.Ti(iPrO)4 (168 mg,.58 mmol) in, tHF (10 mL) was stirred in a microwave reactor at 100 C for.After stirring 2 h, the reaction mixture was treated with NaBH3CN at 0 C, and stirring was continued for another.PE etOAc ) to provide the product as a yellow solid.

The mixture was extracted with.
The mixture was diluted with H2O (20 mL EtOAc (25 mL and sat aq NaHCO3 (10 mL).
The mixture was concentrated and the residue brought to pH 10 using.Patent Reference: WO, page 104, (20.2 MB example 3 To a solution of the SM (1.10 g,.61 mmol) in MeOH (15 mL) was successively added oxetan-3-one (1.66 g,.01 mmol 4A molecular sieves (0.5 g and ZnCl2 (3.14 g,.01 mmol).The layers were separated and the aq layer was further extracted with EtOAc (3 x 25 mL).EtOAc and the org layer was washed with H2O, brine, dried (.By using our site, you agree to our collection of information through the use code reduction sncm of cookies.The crude material was purified by silica gel column chromatography (2.The combined organics were washed with brine (50 mL dried ( Na2SO4 and concentrated.Edu uses cookies to personalize content, tailor ads and improve the user experience.Home, reductive Amination, ex (Nacnbh3) (Nacnbh3 examples: Example 1, to a solution.The reaction mixture was stirred at 50 C for.